Antidepressant and nootropic activity of aqueous extract of Bougainvillea glabra

The aim of this analysis was to assess antidepressant & nootropic capacity Bougainvillea Glabra aqueous extract (BGAE). Forced swim test, tail suspension tetrabenazine mediated catalepsy ptosis models were used BGAE's efficacy in mice at doses 250 500 mg/kg orally. Morris water maze with elevated plus (EPM) test behaviour. Normal medications for function imipramine (25 mg/kg) piracetam (300 mg/kg), respectively. Antioxidant assays such as DPPH TBARS validate function. When comparison car, pre-treatment BGAE resulted substantial dose-dependent decrease immobility time both FST TST. (P0.005) Tetrabenazine-induced decreased dramatically. Furthermore, MWM EPM, demonstrated cognitive enhancing In assay, had IC50 17.39 g/ ml, it 398.71 gm/ ml. has activities that are equivalent mg/kg, respectively, which may be due its effect on neurotransmitters antioxidant